Most children are born healthy, though 2-3% of the children are born with a congenital malformation or will develop cancer at a young age. The causes of most anomalies in children are still largely unknown. For some children, genetic predisposition seems to be an important factor. But circumstances during pregnancy may also play a role, such as health problems of the mother, diet, medication use and occupation of the parents.

The Amalia children’s hospital and the departments of Genetics and Health Evidence of the Radboud university medical center (Radboudumc) started a research project in 2005, named AGORA. This is the abbreviation of Aetiologic research into Genetic and Occupational / Environmental Risk factors for Anomalies in children. This research project aims at building a data- and biobank to facilitate research into the causes of different congenital malformations, such as malformations of the kidneys and urinary tract, intestines and anus, lip and palate, and the heart, but also of childhood cancers.

Blood is drawn and stored from almost every patient attending a paediatric department in the Radboudumc. Blood is also drawn from both biological parents. In addition, the parents are asked to both complete a questionnaire with questions about circumstances around the pregnancy period.

The ultimate goal of AGORA is to investigate whether certain anomalies can be prevented in children in the future.

If you are interested in using data from AGORA for research, please complete this application form and send it to This email address is being protected from spambots. You need JavaScript enabled to view it.

For questions see Contact information.