Researchers – Publications – Hypospadias – etiology

Maternal hypertensive disorders and subtypes of hypospadias: A Dutch case‐control study.

Roeleveld N, van Rooij IALM, van der Zanden LFM, van Gelder MMHJ, Jamaladin H. Paediatr Perinat Epidemiol 2020; 34:687-95.

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Interaction between MTHFR 677C>T and periconceptional folic acid supplementation in the risk of Hypospadias.

Dokter EM, van Rooij IA, Wijers CH, Groothuismink JM, van der Biezen JJ, Feitz WF, Roeleveld N, van der Zanden LF. Birth Defects Res A Clin Mol Teratol 2016;106:275-284.

 

Fine mapping analysis confirms and strengthens linkage of four chromosomal regions in familial hypospadias.

Söderhäll C, Baranowska Körberg I, Thai HTT, Cao J, Chen Y, Zhang X, Shulu Z, van der Zanden LFM, van Rooij IALM, Frisén L, Roeleveld N, Markljung E, Kockum I, Nordenskjöld A. EJHG 2015;23:516-522.

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Sequencing of the DKK1 gene in patients with anorectal malformations and hypospadias.

van de Putte R, Wijers CHW, de Blaauw I, Feitz WFJ, Marcelis CLM, Hakobjan M, Sloots CEJ, van Bever Y, Brunner HG, Roeleveld N, van Rooij IALM, van der Zanden LFM. Eur J Pediatr 2015;175:583-587.

 

Genome-Wide Association Study identifies variants in developmental genes associated with hypospadias.

Geller F, Feenstra B, Carstensen L, Pers TH, van RooijIALM , Baranowska Körberg I, ChoudhryS, Karjalainen J, Schnack TH, Hollegaard MV, Feitz WFJ, Roeleveld N, Hougaard DM, Hirschhorn JN, Franke L, Baskin LS, Nordenskjöld A, van der Zanden LFM, Melbye M. Nat Genet 2014;46:957-963.

 

Risk factors for different phenotypes of hypospadias: results from a Dutch case-control study.

van Rooij IALM, van der Zanden LFM, Brouwers MM, Knoers NVAM, Feitz WFJ, Roeleveld N. BJU Int 2013;112:121-128.

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Exploration of gene-environment interactions, maternal effects, and parent-of-origin effects in the etiology of hypospadias.

van der Zanden LFM, Galesloot TE, Feitz WFJ, Brouwers MM, Shi M, Knoers NVAM, Franke B, Roeleveld N, van Rooij IALM. J Urol 2012;188:2354-2360.

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Aetiology of hypospadias: A systematic review of genes and environment.

van der Zanden LFM, van Rooij IALM, Feitz WFJ, Franke B, Knoers NVAM, Roeleveld N. Hum Reprod Update 2012;18:260-283.

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Common variants in DGKK are strongly associated with risk of hypospadias.

van der Zanden LFM, van Rooij IALM, Feitz WFJ, Knight J, Donders ART, Renkema KY, Bongers EMHF, Vermeulen SHHM, Kiemeney LALM, Veltman JA, Arias-Vásquez A, Zhang X, Markljung E, Qiao L, Baskin LS, Nordenskjöld A, Roeleveld N, Franke B, Knoers NVAM. Nat Genet 2011:43:48-50.

 

Hypospadias: Risk factor patterns and different phenotypes.

Brouwers MM, van der Zanden LFM, de Gier RPE, Barten EJ, Zielhuis GA, Feitz WFJ, Roeleveld N. BJU Int 2010;105:254–262.

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Genetics of hypospadias: Are single-nucleotide polymorphisms in SRD5A2, ESR1, ESR2, and ATF3 really associated with the malformation?

van der Zanden LFM, van Rooij IALM, Feitz WFJ, Vermeulen SHHM, Kiemeney LALM, Knoers NAVM, Roeleveld N, Franke B.  J Clin Endocrinol Metab 2010;95:2384-2390.

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Risk factors for hypospadias.

Brouwers MM, Feitz WF, Roelofs LA, Kiemeney LA, de Gier RP, Roeleveld N. Eur J Pediatr 2007;166:671-678.

 

Hypospadias: a transgenerational effect of diethylstilbestrol?

Brouwers MM, Feitz WF, Roelofs LA, Kiemeney LA, de Gier RP, Roeleveld N. Hum Reprod 2006;21:666-669.

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