Questionnaire data

Mother:

  • Demographic data

age at birth, educational level

  • Family history of congenital malformations and cancer (1st /2nd degree relatives)
  • Fertility issues

assisted reproductive techniques, time to pregnancy, subfertility

  • Birth information

birth weight, gestational age, twinning

  • Pregnancy history

parity, miscarriages, stillbirth

 

Questions about the period 3 months before conception until the end of pregnancy:

  • Maternal health

BMI, chronic diseases, fever, infections, pregnancy complications such as preeclampsia, extreme nausea, and gestational diabetes and exposure to X-rays and anaesthetics

  • Use of medication
  • Lifestyle factors

Folic acid / multivitamin use, smoking, alcohol, coffee, and tea consumption, use of cosmetic products, and stress

  • Leisure time factors

home painting, pesticide use

  • Living environment

living near a waste incinerator or on a farm, having a company with use of chemicals

  • Occupation

type and activities, exposure to various chemicals, fumes, and pesticides

  • Diet

special diets, frequency of many food items

 

Father:

  • Demographic data

age at birth, educational level

  • Family history of congenital malformations and cancer (1st /2nd degree relatives)
  • Fertility issues

fertility problems

 

Questions about the period of 3 months before conception and the  first 4 months of pregnancy:

  • Paternal health

BMI, chronic diseases, fever

  • Use of medication
  • Lifestyle factors

folic acid / multivitamin use, smoking, alcohol, coffee, and tea consumption, use of cosmetic products, and stress

  • Leisure time factors

home painting, pesticide use

  • Occupation

type and activities, exposure to various chemicals, fumes, and pesticides

  • Diet

special diets, frequency of many food items

 

Phenotype data

  • Malformations in:
    • Abdominal and respiratory organs
    • Central nervous system
    • Digestive system
    • Heart Kidneys
    • Lip and palate
    • Skeleton
    • Urogenital system
  • Childhood cancers
  • Existence of a syndrome, association, or sequence
  • VACTERL association
  • No anomalies

 

Administrative data

  • Date of Birth
  • Gender
  • Presence of DNA samples of child and/or parents
  • Presence of questionnaire data

 

For more detailed information please contact the AGORA coordinator (see contact).